Alexander Sorisky

Alexander Sorisky

MD, CM, FRCPC

Senior Scientist Emeritus, Inflammation and Chronic Disease

Ottawa Hospital Research Institute

Active Attending Medical Staff, Division of Endocrinology and Metabolism

The Ottawa Hospital

Professor, Department of Medicine and Department of Biochemistry

Microbiology and Immunology

Contact

613-737-8899 x73320

Bio

Dr. Alexander Sorisky received his medical degree from McGill University and completed the postgraduate program in Medical Biochemistry and Internal Medicine at McGill University and University of Ottawa. He undertook Endocrinology & Metabolism training at the University of Vermont, and continued there as a research fellow supported by MRC (now CIHR), in the Departments of Biochemistry and of Pathology and Molecular Genetics. He returned to Canada, and established his clinical activities and research program in Ottawa.

He is Professor of Medicine and of Biochemistry, Microbiology & Immunology, and a member of the Division of Endocrinology and Metabolism, University of Ottawa. He is Senior Scientist Emeritus in the Inflammation and Chronic Disease Program of the Ottawa Hospital Research Institute at The Ottawa Hospital. His awards include a Medical Research Council of Canada Scholar, a Heart and Stroke Foundation of Ontario Career Investigator, and a Premier's Research Excellence Award of Ontario.

Dr. Sorisky's research interest is cell-surface receptor signal transduction in the context of adipose cell responses, such as differentiation, proliferation, survival, and adipokine production. He aims to understand how disturbances in adipose cell signal transduction networks, regulated by cell-surface tyrosine kinase or G protein-coupled receptors, result in cariometabolic malfunction such as insulin resistance and inflammation.

Research Goals and Interests

Obesity, type 2 diabetes, and cardiovascular disease risk
Adipose progenitor cell fate
Adipocyte biology
Insulin signal transduction
Thyroid stimulating hormone (TSH) signal transduction

Dr. Sorisky's research interest is cell-surface receptor signal transduction in the context of adipose cell responses, such as differentiation, proliferation, survival, and adipokine production. His research group uses primary human adipose cells from patients and established cell lines to understand how disturbances in adipose cell signal transduction networks, regulated by cell-surface tyrosine kinase or G protein-coupled receptors, result in metabolic malfunction such as insulin resistance and inflammation. Through this line of inquiry, he aims to understand the molecular processes that link adipose tissue dysfunction with cardiovascular disease and type 2 diabetes


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