Dr. Parks completed a M.Sc. and Ph.D. in the Department of Molecular Biology and Genetics, University of Guelph (Guelph, Ontario), working on biochemical and genetic characterization of poxvirus replication and recombination. In 1996, Dr. Parks began a Postdoctoral Fellowship with Dr. Frank L. Graham, in the Departments of Biology and Pathology, McMaster University (Hamilton, Ontario), working on the development of novel adenoviral vectors for use as gene delivery vehicles for gene therapy applications. Dr. Parks joined the Ottawa Hospital Research Institute in January 1999.
Last 3 Years
2019
103. Saha, B. and R.J. Parks (2019) Histone deacetylase inhibitor suberoylanilide hydroxamic acid suppresses human adenovirus gene expression and replication. J Virol. 93(12). pii: e00088-19. doi: 10.1128/JVI.00088-19.
104. Del Papa, J., J. Petryk, J.C. Bell, and R.J. Parks (2019) An Oncolytic Adenovirus Vector Expressing p14 FAST Protein Induces Widespread Syncytium Formation and Reduces Tumor Growth Rate In Vivo. Molecular Therapy Oncolytics. 14:107-120.
105. Zhang, Y., C.Y. Han, F.G. Duan, X.X. Fan, X.J. Yao, R.J. Parks, Y.J. Tang, M.F. Wang, L. Liu, B.K. Tsang, E.L. Leung (2019) p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling. Cancer Cell Int. 2019 Jul 19;19:188. doi: 10.1186/s12935-019-0910-2.
106. Han, C.Y., D.A. Patten, S.I. Kim, J.J. Lim, M.K.Y. Siu, Y. Han, E. Carmona, R. Parks, C. Lee, K.K. L. Chan7, J.-L. Ku, E.A. Macdonald, B. Vanderhyden, A.M. Mes-Masson, H.Y. S. Ngan, A. Cheung, Y.S. Song, M.-E. Harper and B.K. Tsang. p53 promotes chemoresponsiveness by regulating Hexokinase II gene transcription and metabolic reprogramming in epithelial ovarian cancer. Molecular Carcinogenesis 2019 Sep 4. doi: 10.1002/mc.23106.
107. Saha, B., O. Varette, W.L. Stanford, J.-S. Diallo and R.J. Parks. Development of a novel screening platform for the identification of small molecule inhibitors of human adenovirus. 2019. Virology 538:24-34.
2020
108. Poulin, K.L, E.R. McFall, G. Chan, N.B. Provost, C. Christou, A.C. Smith, R.J. Parks (2020) Fusion of large polypeptides to human adenovirus type 5 capsid protein IX can compromise virion stability and DNA packaging capacity. J Virol. 17;94(17):e01112-20.
109. Del Papa, J., R.G. Clarkin, R.J. Parks (2020) Use of cell fusion proteins to enhance adenoviral vector efficacy as an anti-cancer therapeutic. Cancer Gene Therapy doi: 10.1038/s41417-020-0192-9.
110. Saha, B. and R.J. Parks (2020) Recent Advances in Novel Antiviral Therapies against Human Adenovirus. Microorganisms 2020, 8, 1284.
111. Jennings, M.R. and R.J. Parks (2020) Antiviral Effects of Curcumin on Adenovirus Replication. Microorganisms 2020, 8, 1524; doi:10.3390/microorganisms8101524.
112. Tzelepis, F., H. Kaur Birdi, A. Jirovec, S. Boscardin, C. Tanese de Souza, M. Hooshyar, A. Chen, K. Sutherland, R. Parks, J. Werier, and J.-S. Diallo (2020) Oncolytic rhabdovirus vaccine boosts chimeric anti-DEC205 priming for effective cancer immunotherapy. Molecular Therapy Oncolytics. doi.org/10.1016/j.omto.2020.10.007.
113. Jennings, M.R. and R.J. Parks (2020) Curcumin as an antiviral agent. Viruses 12:1242; doi.org/10.3390/v12111242.
2021
114. Warman Chardon, J., B.J. Jasmin, R. Kothary and R.J. Parks (2021) Report on the 5th Ottawa International Conference on Neuromuscular Disease and Biology - October 17-19, 2019, Ottawa, Canada. Journal of Neuromuscular Diseases. 8(2):323-334. doi: 10.3233/JND-219001.
115. Saha, B. and R.J. Parks (2021) Identification of human adenovirus replication inhibitors from a library of small molecules targeting cellular epigenetic regulators. Virology 555:102-110. doi: 10.1016/j.virol.2020.07.007.
116. René, C.A. and R.J. Parks (2021) Delivery of therapeutic agents to the central nervous system and the promise of extracellular vesicles. Pharmaceutics 13(4):492. doi: 10.3390/pharmaceutics13040492.
117. Ard, R., J.-C. Maillet, E. Daher, M. Phan, R. Zinoviev, R.J. Parks, and S.H Gee (2021) PKCα-mediated phosphorylation of the diacylglycerol kinase ζ MARCKS domain switches cell migration modes by regulating interactions with Rac1 and RhoA. J Biol Chem. 296:100516. doi: 10.1016/j.jbc.2021.100516.
118. Clarkin, R., J. Del Papa and R.J. Parks. The genome position of a therapeutic transgene strongly influences the level of expression in an armed oncolytic human adenovirus vector. Virology (in press).