Studying the immune response of COVID-19 patients in the ICU
Dr. Shirley MeiResearchers at The Ottawa Hospital are exploring more than 50 research projects to support the world-wide effort to find better ways to treat and prevent COVID-19.
The Ottawa Hospital Foundation's COVID-19 Emergency Response Fund is providing seed funding for a number of these projects, including a study led by Dr. Shirley Mei that will examine why some people get severely ill and die of COVID-19, while others experience only mild symptoms.
Part of the answer may lie in how an individual's immune system reacts (and sometimes over-reacts) to the COVID-19 virus.
Dr. Mei and her intensive care research colleagues will study this in critically ill COVID-19 patients using the world's most advanced "single-cell proteomics" technology. This technology, called CyTOF, will allow the researchers to study up to 60 different biological factors all at the same time from one single cell. The researchers will create a multi-dimensional map of the immune response to COVID-19, showing how it changes over time and how it sometimes goes out of control.
The data will be shared with clinicians and researchers around the world, in order to improve treatment of COVID-19 and save lives.
Research team at The Ottawa Hospital/uOttawa: Shirley Mei, Lauralyn McIntyre, Shane English, Duncan Stewart
External collaborators: Claudia dos Santos (St. Michael's Hospital)
Core Resources at The Ottawa Hospital: Clinical Research Lab, Proteomics, Biorepository
Other funders: Fast Grants
The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa.
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Amelia Buchanan
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Ottawa Hospital Research Institute
Office: 613-798-5555 x 73687
Cell: 613-297-8315
ambuchanan@ohri.ca
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The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation.
