Proteomics Facility-Related Publications



  1. The Proteome of Circulating Large Extracellular Vesicles in Diabetes and Hypertension
    A Abolbaghaei, M Turner, J-F Thibodeau, CE Holterman, CRJ Kennedy, D Burger
    Int J Mol Sci. 2023 24(5):4930

  2. Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
    Geertsma HM, Suk TR, Ricke KM, Horsthuis K, Parmasad JA, Fisk ZA, Callaghan SM, Rousseaux MWC
    Human Molecular Genetics 2022 Feb 18

  3. Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice
    Sincennes M-C, Brun CE, Lin AYT, Rosembert T, Datzkiw D, Saber J, Ming H, Kawabe Y, Rudnicki MA
    Nature Communications 2021 12, 3253

  4. Proximity Interactome Map of the Vac14-Fig4 Complex Using BioID
    S Qiu, M Lavallée-Adam, and M Côté
    J. Proteome Res. 2021 20, 11, 4959-4973

  5. Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites
    Tokarew JM, El-Kodsi DN, et al., Schlossmacher MG
    Acta Neuropathologica 2021 141(5):725-754

  6. A Nuclear Stress Pathway that Parallels Cytoplasmic Stress Granule Formation
    T Quoc-Thai, A Gaudreau-Lapierre, CG Palii, VM Ferreira Resende, D Campuzano, C Simada Aeschimann, M Brand, L Trinkle-Mulcahy
    iScience 2020 Volume 23, Issue 11, 20 November, 101664



  7. PRMT7 methylates eukaryotic translation initiation factor 2a and regulates its role in stress granule formation
    Haghandish N, Baldwin RM, Morettin A, Dawit HT, Adhikary H, Masson JY, Mazroui R, Trinkle-Mulcahy L, Côté J
    Mol Biol Cell. 2019 Mar 15;30(6):778-793

  8. Regulation of ATR activity via the RNA polymerase II associated factors CDC73 and PNUTS-PP1
    Landsverk HB, Sandquist LE, Sridhara SC, Rødland GE, Sabino JC, de Almeida SF, Grallert B, Trinkle-Mulcahy L, Syljuåsen RG
    Nucleic Acids Res. 2019 Feb 28;47(4):1797-1813

  9. The metacaspase Yca1 maintains proteostasis through multiple interactions with the ubiquitin system
    Shrestha A, Brunette S, Stanford WL, Megeney LA
    Cell Discov. 2019 Jan 22;5:6.

  10. Caspase Cleavage of Gelsolin Is an Inductive Cue for Pathologic Cardiac Hypertrophy
    Putinski C, Abdul-Ghani M, Brunette S, Burgon PG, Megeney LA
    J Am Heart Assoc. 2018 Dec 4;7(23):e010404

  11. Identification of Cdk1-LATS-Pin1 as a Novel Signaling Axis in Anti-tubulin Drug Response of Cancer Cells
    Yeung B, Khanal P, Mehta V, Trinkle-Mulcahy L, Yang X
    Mol Cancer Res. 2018 Mar 9

  12. Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease
    Kim K, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE, (CLINT), Park DS
    Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5164-E5173.

  13. The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment
    Chang NC, Sincennes MC, Chevalier FP, Brun CE, Lacaria M, Segalés J, Muñoz-Cánoves P, Ming H, Rudnicki MA
    Cell Stem Cell 2018 May 3;22(5):755-768.

  14. Actin-dependent regulation of cilia length by the inverted formin FHDC1
    Copeland SJ, McRae A, Guarguaglini G, Trinkle-Mulcahy L, Copeland JW
    Mol Biol Cell. 2018 May 9


  15. Cdx2 Regulates Gene Expression through Recruitment of Brg1-associated Switch-Sucrose Non-fermentable (SWI-SNF) Chromatin Remodeling Activity.
    Nguyen TT, Savory JG, Brooke-Bisschop T, Ringuette R, Foley T, Hess BL, Mulatz KJ, Trinkle-Mulcahy L, Lohnes D
    J Biol Chem. 2017 Feb 24;292(8):3389-3399.


  16. UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia
    A Benyoucef, CG Palii, C Wang, CJ Porter, A Chu, F Dai,V Tremblay, P Rakopoulos, K Singh, S Huang, F Pflumio, J Hébert, J-F Couture, TJ Perkins, K Ge, FJ Dilworth, M Brand
    Genes and Development, 2016 Mar 1; 30(5): 508-521

  17. Adaptation to Stressors by Systemic Protein Amyloidogenesis.
    Audas TE, Audas DE, Jacob MD, Ho JJ, Khacho M, Wang M, Perera JK, Gardiner C, Bennett CA, Head T, Kryvenko ON, Jorda M, Daunert S, Malhotra A, Trinkle-Mulcahy L, Gonzalgo ML, Lee S.
    Developmental Cell. 2016 Oct 24;39(2):155-168.



  18. Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes.
    Platani M, Trinkle-Mulcahy L, Porter M, Jeyaprakash AA, Earnshaw WC
     Journal of Cell Biology, 2015 Jul 6;210(1):45-62

  19. Identification of the PRMT1v1 and PRMT1v2 specific interactomes by quantitative mass spectrometry in breast cancer cells
    Baldwin RM, Bejide M, Trinkle-Mulcahy L, Côté J
    Proteomics. 2015 Jul;15(13):2187-97

  20. Extracting, enriching, and identifying nuclear body sub-complexes using label-based quantitative mass spectrometry
    Fox A, Mehta V, Boulon S, Trinkle-Mulcahy L
    Methods in Molelcular Biology, 2015;1262:215-38

  21. Phosphorylation of filamin A by Cdk1 regulates filamin A localization and daughter cell separation
    SG Szeto, EC Williams, AD Rudner, JM Lee
    Experimental Cell Research, 2015. 330(2):248-66

  22. Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells
    S Dick, NC Chang, NA Dumont, RAV Bell, C Putinski, Y Kawabe, DW Litchfield, MA Rudnicki, LA Megeney
    Proceedings of the National Academy of Sciences (PNAS), 2015. 112(38):E5246-52

  23. A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation
    K Singh, M Cassano, E Planet, S Sebastian, SM Jang, G Sohi, H Faralli, J Choi, HD Youn, FJ Dilworth D Trono
    Genes and Development, 2015. 29: 513-525


  24. The human mitotic kinesin KIF18A binds protein phosphatase 1 (PP1) through a highly conserved docking motif
    V De Wever, I Nasa, D Chamousset, D Lloyd, M Nimick, H Xu, L Trinkle-Mulcahy, GBG Moorhead
    Biochemical Biophysical Research Communications, 2014 Oct 24;453(3):432-7


  25. Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking
    Prescott AR, Bales A, James J, Trinkle-Mulcahy L, Sleeman JE
    Journal of Cell Science, 2014 Feb 15;127(Pt 4):812-27


  26. Proteomic analysis implicates translationally controlled tumor protein as a novel mediator of occlusive vascular remodeling in pulmonary arterial hypertension
    JR Lavoie, ML Ormiston, C Perez-Iratxeta, DW Courtman, B Jiang, E Ferrer, P Caruso, M Southwood, WS Foster, NW Morrell, DJ Stewart.
    Circulation. 2014 May 27;129(21):2125-35.


  27. OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand
    DA Patten, J Wong, M Khacho, V Soubannier, RJ Mailloux, K Pilon-Larose, JG MacLaurin, DS Park,HM McBride, L Trinkle-Mulcahy, M Harper, M Germain, RS Slack
    EMBO J. 2014 Nov 18; 33(22): 2676-2691.


  28. Dissection of a Novel Autocrine Signaling Pathway via Quantitative Secretome and Interactome Mapping
    N Lariviere, J Law, L Trinkle-Mulcahy
    Journal of Proteome Research, 2014; 13, 3432 - 3443


  29. Characterization of Angiotensin-Converting Enzyme 2 Ectodomain Shedding from Mouse Proximal Tubular Cells
    F Xiao, J Zimpelmann, S Agaybi, SB Gurley, L Puente, KD Burns
    PLOS One, 2014


  30. Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: a Novel Therapeutic Opportunity for Arterial Repair
    B Hibbert, JR Lavoie, X Ma, T Seibert, JE Raizman, T Simard, YX Chen, D Stewart, ER O'Brien
    Diabetes, 2013

  31. Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation
    S Sebastian, H Faralli, Z Yao, P Rakopoulos, C Palii, Y Cao, K Singh, Q Liu, A Chu, A Aziz, M Brand, SJ Tapscott, FJ Dilworth
    Genes & Development, 2013

  32. Quantitative Fragmentome Mapping Reveals Novel, Domain-specific Partners for the Modular Protein RepoMan (Recruits PP1 Onto Mitotic Chromatin at Anaphase).
    M Prévost, D Chamousset, I Nasa, E Freele, N Morrice, G Moorhead, L Trinkle-Mulcahy
    Mol Cell Proteomics 2013; 12: 1468-1486

  33. Monoclonal antibodies recognizing the surface autolysin IspC of Listeria monocytogenes serotype 4b: epitope localization, kinetic characterization, and cross-reaction studies.
    J Ronholm, H van Faassen, R MacKenzie, Z Zhang, X Cao, M Lin.
    PLoS One. 2013;8(2):e55098. doi: . Epub 2013 Feb 4.

  34. The role of Yca1 in Proteostasis. Yca1 Regulates the Composition of the Insoluble Proteome
    A Shrestha, LG Puente, S Brunette, LA Megeney
    Journal of Proteomics; 2013, Volume 81, Pages 24-30


  35. Carm1 Regulates Pax7 Transcriptional Activity through MLL1/2 Recruitment during Asymmetric Satellite Stem Cell Divisions
    Y Kawabe, YX Wang, IW McKinnell, Bedford, MA Rudnicki
    Cell Stem Cell 2012; 11: 333-345


  36. Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C and the H3K4 demethylase Jarid1a/KDM5A
    C-P Chaturvedi, B Somasundaram, K Singh, RL Carpenedo, WL Stanford, FJ Dilworth, & M Brand
    Proceedings of the National Academy of Sciences (PNAS), 2012, October 29


  37. Resolving protein interactions and complexes by affinity purification followed by label-based quantitative mass spectrometry
    L Trinkle-Mulcahy
    Proteomics 2012; 12: 1623-1638


  38. Wnt7a-Fzd7 signalling directly activates the Akt/mTOR anabolic growth pathway in skeletal muscle
    J von Maltzahn, CF Bentzinger & MA Rudnicki
    Nature Cell Biology, 2011. DOI:10.1038/ncb2404


  39. Paradoxical Increase in Background Phosphorylation of Bmp-Responsive Proteins in Blood-Derived Endothelial Cells From Bmpr2 Mutation Carriers With Hereditary Pulmonary Arterial Hypertension
    J Lavoie, M Ormiston, DW Courtman, NW Morrell, DJ Stewart
    Circulation, 2011; 124: A13520


  40. Quantitative Proteomic Analysis of Dystrophic Dog Muscle
    L Guevel, JR Lavoie, C Perez-Iratxeta, K Rouger, L Dubreil, M Feron, S Talon, M Brand & LA Megeney
    Journal of Proteome Research, 2011. DOI: 10.1021/pr2001385


  41. Wnt11 promotes cardiomyocyte development by caspase-mediated suppression of canonical Wnt signals.
    M Abdul-Ghani, D Dufort, R Stiles, Y De Repentigny, R Kothary & LA Megeney
    Molecular and Cellular Biology, 2011; p. 163-178, Vol. 31, No. 1


  42. Cellular prion protein localizes to the nucleus of endocrine and neuronal cells and interacts with structural chromatin components
    A Strom, GS Wang, DJ Picketts, R Reimer, AW Stuke, FW Scott
    Eur J Cell Biol. 2011; 90(5):414-9.


  43. The Metacaspase Yca1 is required for Clearance of Insoluble Protein Aggregates.
    REC Lee, S Brunet, LG Puente & LA Megeney
    Proceedings of the National Academy of Sciences (PNAS), 2010; 107(30):13348-53


  44. Peripherin-reactive antibodies in mouse, rabbit and human blood.
    A Strom, B Sonier, HD Chapman, M Mojibian, G-S Wang, CR Slatculescu, DV Serreze & FW Scott
    Journal of Proteome Research, 2010, 9 (3), pp 1203-1208.