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Researchers at The Ottawa Hospital awarded 18 CIHR grants worth more than $11 million

Researchers at The Ottawa Hospital are playing a lead role in 18 new projects awarded more than $11 million from the Canadian Institutes of Health Research (CIHR).

These projects will advance science and improve health in areas such as tuberculosis, blood disease, prostate cancer, heart disease, muscle repair, sleep apnea, brain cancer, medical imaging, virtual care, prehab, intellectual disability, sarcoma, CAR-T therapy, kidney disease, patient decision aids, critical care and heat strain.

"Research projects such as these will help us provide the best care possible for our patients and community, while advancing science and improving health on a global scale," said Dr. Duncan Stewart. "I'm proud that The Ottawa Hospital has consistently ranked as one of the top hospitals in the country for highly-competitive CIHR funding, ranking fourth overall in 2020-21."

The new grants include:

Focused community TB screening among high risk residential zones in Nunavut: The TAIMA TB household risk prediction study - $573,750

  • Principal Investigators: Alvarez, Gonzalo G; Mao, Yongyi; Pease, Christopher
  • Co-Investigators: Ward, Leonor; Mulpuru, Sunita; Mallick, Ranjeeta; Zwerling, Alice A; Patterson, Michael; Aaron, Shawn D; McElroy, Linette; Allen, Jean M; Carrington, André; DeMaio, Patricia A; Pearce, Susie

Mechanistic insights into non-malignant hematopoietic diseases - $952,425

The impact of 1-year of adjuvant androgen deprivation following radical prostatectomy on prostate cancer recurrence: An internal pilot randomized trial - $100,000

  • Principal Investigators: Breau, Rodney H; Fergusson, Dean A; Lavallée, Luke T
  • Co-Investigators: Klotz, Laurence H; Nicholls, Stuart G; Cagiannos, Ilias; Hamilton, Robert J; Kassouf, Wassim; Morash, Chris G; Morgan, Scott C; Saad, Fred; Shayegan, Bobby; Ramsay, Timothy O; Rendon, Ricardo

Comparison of Bleeding Risk between Rivaroxaban and Apixaban in Atrial Fibrillation (COBRRA AF) - $2,210,850

  • Principal Investigators: Castellucci, Lana; Le Gal, Grégoire; de Wit, Kerstin; Parkash, Ratika
  • Co-Investigators: Ramsay, Timothy O; Hibbert, Benjamin M; Birnie, David H; Kovacs, Michael J; Thavorn, Kednapa; Schulman, Sam; Healey, Jeff S; Perry, Jeffrey J; Stiell, Ian G; Shivakumar, Sudeep P; Kahn, Susan R; Blostein, Mark D; Campbell, Samuel G

Characterizing the non-redundant roles for histone modifying enzymes in stem cell-mediated muscle repair - $940,950

Assessing the Patient, Provider and Policy Impacts of a Positive Airway Pressure Device Recall for Obstructive Sleep Apnea: A Mixed-Methods Evaluation - $321,300

  • Principal Investigators: Kendzerska, Tetyana; Pendharkar, Sachin R; Ayas, Najib
  • Co-Investigators: Mackenzie, Constance A; Gagliardi, Anna R; Kaminska, Marta; Fenton, Mark E; Povitz, Marcus; Gershon, Andrea S; McBrien, Kerry; Hawken, Steven

A therapeutic strategy for PTEN tumour suppressor restoration in glioblastoma - $738,225

'Living' Systematic Review and IPD Meta-Analysis to Evaluate the Contributions of Major and Ancillary Imaging Features on the Diagnostic Accuracy of LI-RADS - $414,755

  • Principal Investigators: McInnes, Matthew; Chernyak, Victoria; Salameh, Jean-Paul; Tang, An; van der Pol, Christian B; Thombs, Brett D
  • Co-Investigators: Bashir, Mustafa; Kielar, Ania; Sirlin, Claude; Martel, Guillaume; Levis, Brooke; Costa, Andreu F; Kennedy, Erin; Flemming, Jennifer A; Singal, Amit

STRIVE before surgery trial: a vanguard pragmatic multicenter randomized trial of Structured TRaining to Improve fitness in a Virtual Environment before surgery - $260,100

  • Principal Investigators: McIsaac, Daniel I; Kidd, Gurlavine D; Taljaard, Monica; Tandon, Puneeta; Wijeysundera, Duminda N; Mcneely, Margaret L; Gillis, Chelsia A; Hallet, Julie
  • Co-Investigators: Thavorn, Kednapa; Fergusson, Dean A; Martel, Guillaume; Serrano, Pablo E; Khadaroo, Rachel; Eskander, Antoine; Zwarenstein, Merrick F; Lalu, Manoj M; Boland, Laura S; Breau, Rodney H; Bryson, Gregory L; Chesney, Tyler; Forster, Alan J; Gagné, Sylvain; Gill, Marlyn; Lavallée, Luke T; McCartney, Colin J; Moloo, Husein; Scheede-Bergdahl, Celena; Van Walraven, Carl; Vogt, Kelly N; Auer, Rebecca Ann C; Roberts, Derek J; Hladkowicz, Emily

The Canadian Prehabilitation Network Review: a systematic review and component network meta-analysis to inform prehabilitation design and evaluation - $100,000

  • Principal Investigators: McIsaac, Daniel I; Hutton, Brian E; Gillis, Chelsia A; Gill, Marlyn; Boland, Laura S
  • Co-Investigators: Lalu, Manoj M; Eskander, Antoine; Scheede-Bergdahl, Celena; Fergusson, Dean A; Khadaroo, Rachel; Veroniki, Areti Angeliki; Wijeysundera, Duminda N; Grudzinski, Alexa L; Fiore Jr, Julio F; Bryson, Gregory L; Beaule, Paul E; Nantel, Julie; McCartney, Colin J; Martel, Guillaume; Carli, Francesco; Poitras, Stéphane; Taljaard, Monica; Holroyd-Leduc, Jayna M; Forster, Alan J; Auer, Rebecca Ann C; Aucoin, Sylvie D

Characterizing the genetic consequences of dysfunctional NURF chromatin remodeling to syndromal intellectual disability - $902,700

The Effect of Incisional Negative Pressure Wound Therapy on Wound Complications Following Sarcoma Surgery in Patients with perioperative radiation therapy; A Multicenter Randomized Clinical Trial - $397,801

  • Principal Investigators: Werier, Joel M; Abdelbary, Hesham; Ghert, Michelle A
  • Co-Investigators: Thavorn, Kednapa; Ferguson, Peter C; Wunder, Jay S; Poitras, Stéphane; Ramsay, Timothy O; Wilson, David

A Phase I first-in-human trial of CLIC-2201, a VHH-CD22 CAR-T cell product for the treatment of relapsed/refractory CD22 positive B-cell non-Hodgkin lymphoma - $1,667,700

  • Principal Investigators: Hay, Kevin A; Kekre, Natasha
  • Co-Investigators: Atkins, Harold L; Bell, John C; Holt, Rob; McComb, Scott R; Nelson, Brad H
  • Note: this grant is administered at BC Cancer

Improving cardiovascular risk prediction in patients with glomerular disease - $236,385

  • Principal Investigators: Barbour Sean; Canney, Mark; Fordyce, Christopher B
  • Co-Investigators: Hladunewich, Michelle A
  • Note: this grant is administered at the University of British Columbia

Liberation from mechanical ventilation using Extubation Advisor Decision Support: The multicentre (LEADS) Pilot Trial - $595,000

  • Principal Investigators: Burns KEA; Seely AJ
  • Co-Investigators: Charbonney E; Ferguson N; Green R; Kutsogiannis D; Kyeremanteng K; Lellouche F; Maslove D; Ramsay T; Rochwerg B; Scales D; Taljaard M; Thovorn K
  • Note: this grant is administered at Unity Health

Effectiveness of patient decision aids and their elements for achieving quality health decisions: systematic review with network meta-analysis to inform and update the international standards - $198,900

  • Principal Investigators: Dawn Stacey, Krystina Brigitte Lewis, Maureen Mary Smith, Robert J. Volk
  • Co-Investigators: M. Barry; C. Bennett; P. Bravo; J. Finderup; A. Gogovor; I. Graham; J. Gunderson; F. Légaré; L. Pacheco-Brousseau; H. Sondergaard; K. Steffensen; M. Trenaman; L. Trevena; G. Wells
  • Note: this grant is administered at the University of Ottawa

CANada in the INCremental dialysis to improve Health outcomes in people starting Hemodialysis (CAN INCH-HD) study: a randomized controlled trial - $654,075

  • Principal Investigators: Charmaine Elizabeth Lok; Deborah Lynn Zimmerman
  • Co-Investigators: S. Dixon; A. Gafni; A. Garg; C. Hawley; S. Kosa; L. Moist; A. Viecelli
  • Note: this grant is administered at the University Health Network

Evaluating the effectiveness of commonly recommended heat-mitigation strategies for limiting heat strain in elderly adults during extreme heat events - $952,425

  • Principal Investigators: Kenny, Glen P; Boulay, Pierre; Malcolm, Janine C; Ruzicka, Marcel; Sigal, Ronald J; Toupin April, Karine
  • Co-Investigators: Akerman, Ashley P; McCormick, James J; Meade, Robert D; Notley, Sean R; Wright, Heather E
  • Note: this grant is administered at the University of Ottawa

The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation. 

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The Ottawa Hospital is a leading academic health, research and learning hospital proudly affiliated with the University of Ottawa and supported by The Ottawa Hospital Foundation.