David Cook
PhD
Scientist, Cancer Research
Ottawa Hospital Research Institute
Assistant Professor, Department of Cellular and Molecular Medicine
University of Ottawa
Contact
613-737-7700 ext 70335
Ottawa Hospital Research Institute Centre for Cancer Therapeutics 501 Smyth Road Box 926 Ottawa, ON K1H 8L6
Research Groups
Cook Lab
Bio
Dr. Cook obtained his PhD with Dr. Barbara Vanderhyden from the University of Ottawa, combining high-throughput screening and single-cell genomics to study epithelial-mesenchymal plasticity in cancer. This phenomenon describes the capacity of malignant cells to dedifferentiate, increasing their ability to invade surrounding tissue, evade immune detection, and resist therapeutics. During this period, he also worked on preclinical models of ovarian cancer to study disease biology and therapeutic testing. For his postdoctoral studies, Dr. Cook worked with Dr. Jeff Wrana (Lunenfeld-Tanenbaum Research Institute, Toronto, ON) to study how cellular phenotypes and tissue structure influence one another.
Dr. Cook is a recipient of the CIHR Banting Fellowship, the OICR Rising Star Award, and the Worton Researcher in Training Award.
News
Publications
Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets
2025-12-03 Go to publicationMapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension
2025-10-28 Go to publicationLINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs
2025-01-01Single-Cell RNA Sequencing Reveals Repair Features of Human Umbilical Cord Mesenchymal Stromal Cells
2024-01-01The Drosophila adult midgut progenitor cells arise from asymmetric divisions of neuroblast-like cells
2024-01-01Related Research at The Ottawa Hospital
- Cancer Research Program
- Cancer
- Ovarian cancer
- Discovery research
- Drug development
- Genomics
- Imaging
- Immunotherapy
- Bioinformatics
- Molecular and cellular biology
- Translational research
- Epigenetics
- Cell therapy
- Gene expression
- Systems biology
- Biomarkers
- RNA sequencing
- Cancer immunotherapy
- Big data
- Cancer biotherapeutics
- Artificial intelligence and data science