Theodore Perkins
BA, MSc, PhD
Senior Scientist, Regenerative Medicine
Ottawa Hospital Research Institute
Associate Professor, Biochemistry, Microbiology and Immunology
University of Ottawa
Research Groups
Perkins Lab
Bio
Dr. Perkins is a Computer Scientist specializing in AI/Machine Learning and Bioinformatics methods for analyzing clinical and molecular biology data, especially high-throughput "Omics" data. He develops new algorithms and representations, particularly focused on gene regulatory networks, epigenomics, and biomarker discovery. He works with biologists and clinicians and numerous applications of these ideas, with a particular emphasis on muscle stem cells and degenerative diseases, and blood development and leukemias. He also has a broader interest in development, including in model organisms such as Drosophila and C. Elegans, as well as human development.
He holds a BA from Carleton College with a Major in Computer Science, an MSc in Computer Science from the University of Wisconsin-Madison, and a PhD in Computer Science from the University of Massachusetts Amherst. His PhD was done under the supervision of Prof. Andrew Barto, one of the co-founders of the subfield of AI called Reinforcement Learning, and focused on Safety in AI. He did Postdoctoral training at McGill University under Profs. Leon Glass and Michael Hallett.
Dr. Perkins is also an Associate Professor with the Department of Biochemistry, Microbiology, and Immunology in the Faculty of Medicine at the University of Ottawa, with cross-appointments to the Department of Cellular and Molecular Medicine, the School of Electrical Engineering and Computer Science, and the Ottawa-Carleton Institute of Biomedical Engineering.
News
Publications
Histone Modification Metapeaks are Epigenetic Landmarks Predictive of Cell State
2026-04-02 Go to publicationMetabolic, epigenetic and transcriptomic alterations in postnatal 16p11.2-deficient murine astrocytes
2025-12-17 Go to publicationSpatiotemporal remodeling of chromatin topology architecture and H3K27me3 redistribution underlies vascular pathology in Hutchinson-Gilford progeria syndrome
2025-12-15 Go to publicationDifferential equation modeling of cell population dynamics in skeletal muscle regeneration from single-cell transcriptomic data
2025-10-10 Go to publicationGenetic network structure and dynamics: identifying simple negative feedback loops
2025-08-22 Go to publicationRelated Research at The Ottawa Hospital
- Regenerative Medicine Program
- Musculoskeletal conditions
- Neuromuscular disease
- Brain and neuromuscular disease
- Cancer
- Muscular dystrophy
- Discovery research
- Genetics
- Genomics
- Bioinformatics
- Proteomics
- Regenerative medicine
- Biostatistics
- Translational research
- Epigenetics
- Gene expression
- Systems biology
- Stem cells
- Biomarkers
- Big data
- Artificial intelligence and data science