Colorectal cancer
On this page:
The Ottawa Hospital is conducting cutting-edge research to improve our understanding of colorectal cancer and develop better approaches for treatment and prevention. This page includes selected news stories about our colorectal cancer research, links to researchers working in this area and related resources. Learn more below.
Research & News
Labs and Groups
These research teams may include multiple scientists, investigators, staff and trainees all working towards a common goal, or they can represent a single scientist and their team.
Ardolino Cancer Immunology Lab
Auer Lab
Clinical Trials
The following list of clinical trials at The Ottawa Hospital is pulled from ClinicalTrials.gov, which is hosted by the U.S. National Library of Medicine and only available in English. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. If you email the study team directly, we can guarantee a response. Learn more about participating in research and clinical trials.
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (NCT06662786)
Colorectal Neoplasms View DetailsA Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver (NCT05677113)
Colorectal Cancer, Liver Metastases View DetailsMOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors (NCT06586515)
Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer View DetailsA Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors (NCT06131840)
Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Pancreatic Ductal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small Cell Lung Carcinoma View DetailsThe DRAGON 2 Trial (NCT05428735)
Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR) View DetailsStudy of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC) (NCT06462183)
Adenoid Cystic Carcinoma, Colorectal Cancer View DetailsA Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05581004)
Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma, TNBC, Esophageal Cancer, Gastric Cancer, Cervical Cancer, Colorectal Cancer, Urothelial Carcinoma, Clear Cell RCC, HCC View DetailsAnti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01) (NCT05464030)
Colorectal Cancer View DetailsA Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130)
Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer View DetailsA Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701)
Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma, Advanced Colorectal Cancer (Part 1) View DetailsA Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (NCT05379595)
Advanced or Metastatic Colorectal Cancer View DetailsBOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours (NCT04421820)
Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma View DetailsA Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (NCT05253651)
Colorectal Neoplasms View DetailsA Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709)
Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms View DetailsA Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer (NCT04486378)
Colorectal Cancer Stage II, Colorectal Cancer Stage III View DetailsOntario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943)
Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary Cancer View DetailsA Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A) (NCT06428409)
Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer View DetailsPublications
The following research publications from The Ottawa Hospital are pulled from PubMed, with publication date of 2020 or later. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.
Accuracy and reproducibility of large language model measurements of liver metastases: comparison with radiologist measurements.
2025-10-04 Go to publicationEmbryonic Signaling Pathways Shape Colorectal Cancer Subtypes: Linking Gut Development to Tumor Biology.
2025-10-01 Go to publicationGravida and Birth Outcomes Prior to and after Diagnosis of Early Age-Onset Colorectal Cancer among Female Patients: Population-Based Epidemiologic Studies.
2025-09-02 Go to publicationSexual health outcomes after colorectal cancer diagnosis in females: a population-based cohort study.
2025-09-01 Go to publicationCanadian considerations on updating the age of initiation for colorectal cancer screening in individuals at average risk.
2025-08-08 Go to publication