Michele Ardolino

Michele Ardolino

PhD

Senior Scientist, Cancer Research

Ottawa Hospital Research Institute

Assistant Professor, Department of Biochemistry

Microbiology and Immunology

Research Groups

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Research Group
Ardolino Cancer Immunology Lab
Why don't the Killers kill? Understanding the immune system to develop better immunotherapy The immune system is an incredible weapon against...

Bio

As a young student, I found myself amazed by the combination of elegance and efficiency displayed by the immune system. Once I completed my master in Biotechnology, I enthusiastically joined the Immunological Science program at the University of Rome as a Ph.D student. In the laboratory directed by Angela Santoni, I studied how two populations of immune cells, T cells and NK cells, interact with each other in the human system. After graduation, I decided to move to the US for my post-doctoral training, and in 2010 I joined the group of David Raulet at the University of California, Berkeley. In David’s lab, I have investigated the mechanisms that underlie the failure of the immune response to tumors. I received invaluable training in mouse and tumor immunology during my time in the Raulet lab and I became an expert in the immuno-oncology field. In 2016, I was recruited by a joint effort of the University of Ottawa and the Ottawa Hospital Research Institute to lead a group in cancer immunology. My laboratory is interested in understanding the complex interactions between immune cells and tumors to find new ways to harness the immune system against cancer.


News


Publications

Sox10-Deficient Drug-Resistant Melanoma Cells Are Refractory to Oncolytic RNA Viruses

2023-12-29 Go to publication

A New Functional Screening Platform Identifies Colistin Sulfate as an Enhancer of Natural Killer Cell Cytotoxicity

2022-06-08 Go to publication

Immunotherapy for sarcomas: new frontiers and unveiled opportunities

2021-02-01 Go to publication

Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice

2021-01-01

Related Research at The Ottawa Hospital