Cancer
On this page:
The Ottawa Hospital is conducting cutting-edge research to improve our understanding of cancer and develop better approaches for treatment and prevention. This page includes selected news stories about our cancer research and links to researchers working in this area. Please also visit our Cancer Research Program webpage.
Research & News
Labs and Groups
These research teams may include multiple scientists, investigators, staff and trainees all working towards a common goal, or they can represent a single scientist and their team.
Addison Cancer Research Lab
Ardolino Cancer Immunology Lab
Auer Lab
Bell Lab
BMC VMF Group
Cook Lab
Crawley Lab
Diallo Lab
Doug Manuel Lab
Gray Lab
HERO Group (Dr. Thavorn)
LIU Lab
Perkins Lab
REthinking Clinical Trials
Urologic Oncology Group
Vanderhyden Lab
Clinical Trials
The following list of clinical trials at The Ottawa Hospital is pulled from ClinicalTrials.gov, which is hosted by the U.S. National Library of Medicine and only available in English. If you find a clinical trial that interests you, you can bring the information to the next appointment with your care team and ask if you are eligible for the study. If so, they may be able to refer you to the study team. If you email the study team directly, we can guarantee a response. Learn more about participating in research and clinical trials.
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer (NCT06662786)
Colorectal Neoplasms View DetailsSecondary Prevention of VTE in Patients With Cancer and Catheter-Related Upper Extremity Deep Vein Thrombosis (NCT06603870)
Venous Thromboembolism, Cancer, Upper Extremity Deep Vein Thrombosis, Catheter-Related Infections View DetailsAdjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer (NCT05849129)
Lung Cancer View DetailsPrimary Thromboprophylaxis in Patients With Malignancy and Central Venous Catheters (NCT05029063)
Venous Thromboembolism, Cancer View DetailsTucatinib With Brain and/or Spinal XRT in Patients With HER2+ Metastatic Breast Cancer and LMD (NCT06016387)
HER2-positive Breast Cancer, LMD View DetailsPhotobiomodulation for the Prevention of Radiation Induced Oral Mucositis (NCT04671862)
Mucositis Oral, Head and Neck Cancer, Radiation Dermatitis View DetailsNicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial (NCT05955924)
Non-melanoma Skin Cancer, Carcinoma, Squamous Cell, Carcinoma, Basal Cell, Keratinocyte Carcinoma View DetailsA Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver (NCT05677113)
Colorectal Cancer, Liver Metastases View DetailsMOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors (NCT06586515)
Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung Cancer, Colorectal Cancer View DetailsImpact of Hormonal Therapy on Prostate Cancer Recurrence After Radical Prostatectomy (NCT05169112)
Prostate Cancer View DetailsThe Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III (NCT04871412)
Lung Cancer, Gastric Cancer, Esophageal Cancer View DetailsA Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors (NCT06131840)
Colorectal Neoplasms, Carcinoma, Non-Small-Cell Lung, Stomach Neoplasms, Pancreatic Ductal Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Small Cell Lung Carcinoma View DetailsNeoadjuvant Upper Tract Invasive Cancer Trial (NAUTICAL) (NCT04574960)
Bladder Cancer, Bladder Urothelial Carcinoma View DetailsThe DRAGON 2 Trial (NCT05428735)
Colorectal Cancer Liver Metastases (CRLM), Small Future Liver Remnant (FLR) View DetailsPrevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) (NCT04874038)
Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, Chronic View DetailsPlatelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (NCT04448184)
Hematologic Neoplasms View DetailsOsimertinib Then Chemotherapy in EGFR-mutated Lung Cancer with Osimertinib Third-line Rechallenge (NCT04335292)
Non-Small Cell Lung Cancer View DetailsProspectively Defining Metastatic Pancreatic Ductal Adenocarcinoma Subtypes by Comprehensive Genomic Analysis (NCT02869802)
Cancer, Pancreatic Cancer View DetailsDevelopment of a Risk Stratification Score for Recurrent Venous Thromboembolism and Treatment-related Clinically Relevant Bleeding in Patients With Cancer-associated Thrombosis (NCT06894576)
Cancer-associated Thrombosis View DetailsVTE Prevention With Rivaroxaban in Genitourinary Cancer Patients Receiving Systemic Therapy (NCT05920343)
Venous Thromboembolism, Urologic Cancer View DetailsStudy of Safety and Efficacy of RGT-61159 in Adults With Relapsed/Refractory Adenoid Cystic Carcinoma (ACC) or Colorectal Carcinoma (CRC) (NCT06462183)
Adenoid Cystic Carcinoma, Colorectal Cancer View DetailsA Study to Compare the Results of FGFR Testing by Either ctDNA Blood Testing or Standard Tumor Tissue Testing (NCT06129084)
Metastatic Bladder Cancer, Metastatic Urothelial Carcinoma View DetailsCessation of Somatostatin Analogues After PRRT in Mid, Hind-Gut and Pancreatic Neuroendocrine Tumours (NCT06345079)
Neuroendocrine Tumors View DetailsIBD Neoplasia Surveillance RCT (NCT05809999)
Colonic Neoplasms, Inflammatory Bowel Diseases, Dysplasia View DetailsLiquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer (NCT05601440)
Breast Cancer View DetailsA Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors (NCT06157892)
Breast Neoplasms, Gastroesophageal Junction Adenocarcinoma, HER2 Low Breast Neoplasms, HER2 Positive Breast Neoplasms, Stomach Neoplasms, Triple Negative Breast Neoplasms, Metastatic Breast Cancer, Metastatic Gastric Cancer, Advanced Breast Cancer, Advanced Gastric Cancer View DetailsEvaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation (NCT05696626)
Metastatic Breast Cancer View DetailsSafety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction (NCT04680442)
Breast Cancer, Heart Failure View DetailsStudy of CTDNA Response Adaptive Immuno-Chemotherapy in NSCLC (NCT04093167)
Non-Small Cell Lung Cancer View DetailsA Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE (NCT05171075)
Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolism View DetailsScreening for Occult Malignancy in Patients with Unprovoked Venous Thromboembolism (NCT04304651)
Embolism and Thrombosis View DetailsA Phase II Study of Durvalumab Treatment - Substudy A: In Patients Who Discontinued Prior Checkpoint Therapy Due to Immune Related Toxicity - Substudy B: For Continued Treatment (+/- Tremelimumab) of Patients Previously Enrolled to Completed CCTG Studies (NCT03847649)
Cancer View DetailsPhase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 (NCT04613596)
Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer View DetailsCAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS) (NCT04151342)
Cancer, Malignancies Multiple, Malignant Solid Tumor, Cancer, Therapy-Related, Molecular Sequence Variation, Genetic Alteration, Gene Fusion, Receptor Tyrosine Kinase Gene Mutation, RTK Family Gene Mutation, Ras (Kras or Nras) Gene Mutation View DetailsCanadian Profiling and Targeted Agent Utilization Trial (CAPTUR) (NCT03297606)
Lymphoma, Non-Hodgkin, Multiple Myeloma, Advanced Solid Tumors View DetailsStudy of GS-2121 Given Alone or in Combination in Adults With Advanced Solid Tumors (NCT06532565)
Advanced Solid Tumors View DetailsDose Escalation For INtraprostatic LEsions (NCT05851547)
Prostatic Neoplasms View DetailsCold Versus Room Temperature Storage of Platelets for Bleeding in Hematologic Malignancy - a Pilot Trial (NCT05820126)
Hematologic Malignancy View DetailsSNV4818 in Participants With Advanced Solid Tumors (NCT06736704)
Advanced Solid Tumors View DetailsA RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (NCT03127631)
Prostate Cancer, Cardiovascular Disease View DetailsCLIC-2201 for the Treatment of Relapsed/Refractory B Cell Malignancies (NCT06208735)
B-Cell Leukemia, Non-Hodgkin's Lymphoma, B-cell Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Primary Mediastinal Large B-cell Lymphoma (PMBCL), Mantle Cell Lymphoma, B-cell Lymphoma View DetailsEvaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel Chemotherapy (NCT05753618)
Early-stage Breast Cancer View DetailsInternational Registry for Men With Advanced Prostate Cancer (IRONMAN) (NCT03151629)
Prostate Cancer View DetailsA Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors (NCT06384352)
Advanced Solid Tumors View DetailsA Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors (NCT06618287)
Lung Cancer, Breast Cancer View DetailsJoLT-Ca Sublobar Resection (SR) Versus Stereotactic Ablative Radiotherapy (SAbR) for Lung Cancer (NCT02468024)
Non-Small Cell Lung Cancer View DetailsEvaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy (NCT04928261)
Breast Cancer View DetailsA Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer (NCT06790693)
Breast Cancer View DetailsA Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation (NCT06179160)
Solid Tumors View DetailsTRIple Negative Breast Cancer Markers In Liquid Biopsies Using Artificial Intelligence (NCT04874064)
Breast Cancer View DetailsA Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer (NCT06435429)
Metastatic HER2-positive Breast Cancer View DetailsA Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation (NCT05789082)
Non-Small Cell Lung Cancer View DetailsGenomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer (NCT04812366)
Prostate Cancer View DetailsA Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors (NCT05581004)
Locally Advanced or Metastatic Solid Tumors, NSCLC, HNSCC, Melanoma, TNBC, Esophageal Cancer, Gastric Cancer, Cervical Cancer, Colorectal Cancer, Urothelial Carcinoma, Clear Cell RCC, HCC View DetailsAnti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01) (NCT05464030)
Colorectal Cancer View DetailsA Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors (NCT05538130)
Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Colorectal Cancer View DetailsA Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. (NCT05355701)
Melanoma, Non-Small-Cell Lung Cancer, Thyroid Cancer, Glioma, Advanced Colorectal Cancer (Part 1) View DetailsA Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer (NCT05379595)
Advanced or Metastatic Colorectal Cancer View DetailsA Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers (NCT04260802)
Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer, Gastric Cancer, Cervical Cancer, Ovarian Cancer, Hepatocellular Carcinoma, Squamous Cell Carcinoma of Head and Neck, Urothelial Carcinoma, Urothelial Neoplasm, Non Small Cell Lung Cancer, Renal Cell Carcinoma, Locally Advanced Solid Tumor, Locally Advanced Malignant Neoplasm, Squamous Cell Carcinoma, Sarcoma, Merkel Cell Carcinoma, Bladder Cancer View DetailsA Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1) (NCT05384626)
Locally Advanced Solid Tumor, Metastatic Solid Tumor View DetailsCLIC-1901 for the Treatment of Patients With Relapsed/Refractory CD19 Positive Hematologic Malignancies (NCT03765177)
Acute Lymphoblastic Leukemia, Non-Hodgkin's Lymphoma, Chronic Lymphocytic Leukemia View DetailsBOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours (NCT04421820)
Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma View DetailsStudy of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003) (NCT06136624)
Prostate Cancer Metastatic View DetailsA Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (NCT05253651)
Colorectal Neoplasms View DetailsATr Inhibitor in Combination With Olaparib/Durvalumab (MEDI4736) in Gynaecological Cancers With ARId1A Loss or no Loss (NCT04065269)
Gynaecological Cancers View DetailsA Study of BMS-986340 as Monotherapy and in Combination With Nivolumab or Docetaxel in Participants With Advanced Solid Tumors (NCT04895709)
Cervical Cancer, Gastric/Gastroesophageal Junction Adenocarcinoma, Microsatellite Stable Colorectal Cancer, Non-Small-Cell Lung Cancer, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Urothelial Carcinoma, Pancreatic Adenocarcinoma, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms View DetailsPSMA-PET Registry for Recurrent Prostate Cancer (NCT03718260)
Recurrent Prostate Cancer View DetailsEfficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003) (NCT04728893)
Hematologic Malignancies, Waldenstroms Macroglobulinaemia, Non-Hodgkins Lymphoma, Chronic Lymphocytic Leukaemia View DetailsStudy Looking at Biomarkers in Ovarian Cancer (NCT03419689)
Gynecologic Cancer View DetailsTumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study (NCT04589845)
Solid Tumors View DetailsA Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test (NCT04529122)
Solid Tumours View DetailsA Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer (NCT04486378)
Colorectal Cancer Stage II, Colorectal Cancer Stage III View DetailsOntario-wide Cancer TArgeted Nucleic Acid Evaluation (NCT02906943)
Breast Cancer, Lung Cancer, Colorectal Cancer, Melanoma, Gynecological Cancer, Genitourinary Cancer, Pancreatobiliary Cancer, Gastrointestinal Cancer, Head and Neck Cancer, Rare Cancer, Unknown Primary Cancer View DetailsDocetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response (NCT06592924)
Prostate Cancer (Adenocarcinoma) View DetailsA Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A) (NCT06428409)
Colorectal Cancer, Pancreatic Ductal Adenocarcinoma, Biliary Tract Cancer View DetailsSacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012) (NCT06393374)
Triple-Negative Breast Cancer View DetailsNeoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer (NCT06205485)
Rectal Cancer View DetailsComparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial (NCT05773274)
Metastatic Digestive System Neuroendocrine Tumor G1, Metastatic Digestive System Neuroendocrine Tumor G2, Unresectable Digestive System Neuroendocrine Tumor G1, Unresectable Digestive System Neuroendocrine Tumor G2 View DetailsA Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004) (NCT06136650)
Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms View DetailsTesting the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study (NCT05987241)
Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma, Muscle Invasive Ureter Urothelial Carcinoma, Muscle Invasive Urethral Urothelial Carcinoma, Stage II Bladder Urothelial Carcinoma AJCC v6 and v7, Stage III Bladder Urothelial Carcinoma AJCC v6 and v7, Stage IV Bladder Urothelial Carcinoma AJCC v7 View DetailsTesting Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer (NCT05946213)
Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8, Stage IVA Prostate Cancer AJCC v8 View DetailsPembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab (NCT05812807)
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Early Stage Triple-Negative Breast Carcinoma View DetailsTesting the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer (NCT05624996)
Locally Advanced Lung Non-Small Cell Carcinoma, Stage IIB Lung Cancer AJCC v8, Stage III Lung Cancer AJCC v8 View DetailsMirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer (NCT05445778)
Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer View DetailsColon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (NCT05174169)
Stage III Colon Cancer View DetailsTesting the Use of the Usual Chemotherapy Before and After Surgery for Removable Pancreatic Cancer (NCT04340141)
Pancreatic Adenosquamous Carcinoma, Resectable Pancreatic Adenocarcinoma, Pancreatic Cancer View DetailsRegional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer (NCT03488693)
Breast Cancer View DetailsLong-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587) (NCT03486873)
Solid Tumors, Hematologic Malignancies View DetailsBlastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) International Registry (NCT05430971)
Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) View DetailsPublications
The following research publications from The Ottawa Hospital are pulled from PubMed, with publication date of 2020 or later. Note that PubMed is hosted by the U.S. National Library of Medicine and is only available in English.
A Multicenter Prospective Cohort Study on the Use of Weight-Adjusted Dalteparin in Patients Over 90 kg With Acute Cancer-Associated Venous Thromboembolism-The WAVe Study.
2026-01-01 Go to publicationIncidence of Local Treatment and Metastasis During Active Surveillance for Patients With a Small Renal Mass in a National Multicenter Prospective Cohort.
2026-01-01 Go to publicationHER2CLIMB-05: A Phase 3 Study of Tucatinib Versus Placebo in Combination with Trastuzumab and Pertuzumab as First-line Maintenance Therapy for HER2+ Metastatic Breast Cancer.
2025-12-10 Go to publicationPredictors of clinically relevant bleeding during extended anticoagulation for cancer-associated venous thromboembolism (API-CAT): a post-hoc analysis of a randomised, non-inferiority trial.
2025-12-06 Go to publicationSafety and efficiency of D-dimer testing in combination with clinical decision rules to exclude pulmonary embolism in patients with cancer: individual patient data meta-analysis.
2025-12-05 Go to publicationResources
Search for clinical trials at The Ottawa Hospital related to this disease or condition.